James D. Watson, whose co-discovery of the twisted-ladder structure of DNA in 1953 helped catalyze a revolution in medicine and genetics, has died at the age of 97. Watson's groundbreaking work at just 24 years old established him as an iconic figure in the scientific community. However, his later life was overshadowed by controversial statements that sparked professional censure.

Sharing the 1962 Nobel Prize with Francis Crick and Maurice Wilkins, Watson unlocked the secrets of deoxyribonucleic acid (DNA), revealing its double helix structure which resembles a twisting ladder. This discovery altered our understanding of heredity and cellular reproduction, serving as the foundation for advancements in genetic research.

The double helix became a symbol even beyond the scientific world, inspiring art and pop culture, making DNA a part of the public consciousness.

Despite his scientific success, Watson's later years were marred by racist comments regarding intelligence in different races, which led to his suspension from various positions and resulted in a diminished reputation. Dr. Francis Collins, director of the National Institutes of Health, remarked on the troubling nature of Watson's late-career remarks, emphasizing a stark disconnect between his remarkable scientific achievements and his troubling views on humanity.

Throughout his career, Watson contributed to vital scientific projects, including the Human Genome Project, steering funding towards research on the ethics of genetic manipulation. He passed away in hospice, with his son emphasizing his lifelong dedication to helping those afflicted by disease.

Born in Chicago on April 6, 1928, Watson showed precocious intellectual gifts early on, entering the University of Chicago at 15. His passion for genetics ignited at 17, following a profound realization about the essential role genes play in life. This fascination eventually led to his historic collaboration with Crick, which unfolded at Cambridge University and culminated in one of science's most famous discoveries.

The dual nature of Watson’s legacy—illuminated by immense scientific achievement yet clouded by personal controversy—will be remembered in the annals of history as a complex tapestry of brilliance and racial insensitivity.

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