Gates vowed to donate 99% of his wealth by 2045, highlighting Africa as a primary focus of this philanthropic drive. In light of reduced U.S. aid due to shifting political priorities, his foundation seeks to address pressing health challenges, particularly maternal and child health. He remarked on the importance of proper nutrition for mothers and children as a foundation for strong health.

At the African Union headquarters, Gates expressed his hope that young entrepreneurs would leverage AI technologies to improve healthcare systems, drawing attention to Rwanda’s use of AI in managing high-risk pregnancies. His foundation, aiming to end preventable mother and child deaths, combat infectious diseases, and reduce poverty, plans to phase out its operations by 2045.

Gates’ commitment has received a warm welcome from figures like Mozambique's former First Lady, Graça Machel, who views this initiative as essential during challenging times. However, his foundation faces criticism for its influence and financial strategies. Gates’ philanthropic approach, inspired by leaders like Warren Buffett, aims to change perceptions about wealth accumulation, insisting that he wants to be remembered for his generosity rather than his riches.

Gates is also confronting skepticism regarding the effectiveness of large philanthropic foundations while maintaining his vision for a better future in Africa.